Depression: Omega-3 for Memory Problems in Seniors
Fish oil reduces memory problems in elderly patients
High levels of Omega-3 can improve memory in those suffering from depression in old age. This was discovered by researchers from the Medical University of Taipei (Taiwan) and King’s College London (UK) in a study published in the American Journal of Clinical Nutrition. According to the results, cognitive and memory benefits observed in this research are associated with marine-derived Omega-3s, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as alpha-linolenic acid (ALA), the predominant Omega-3 in plants.
Omega-3 and brain health
Omega-3 fatty acids make up more than 60% of brain mass, concentrating in the membranes. Research over the years has shown their presence is essential for the multiplication and differentiation of nerve cells. Neurons need these nutrients to receive or release neurotransmitters, molecules necessary for transmitting nerve impulses. The efficiency of this process is important in preventing certain diseases. For example, low serotonin levels increase the incidence of depression. A dopamine deficiency is associated with a higher risk of developing Parkinson’s disease or attention deficit disorder, a condition characterized by decreased ability to focus on immediate tasks. Some studies suggest that high doses of fish oil, rich in Omega-3 fatty acids, help maintain adequate levels of both serotonin and dopamine. These fatty acids may also be useful in treating depression symptoms. Conversely, irregular Omega-3 intake may contribute to the development of major known forms of this disease.
Omega-3 to awaken memory
The study published in the American Journal of Clinical Nutrition involved 132 elderly individuals with recurrent depression. The authors analyzed Omega-3 levels in the membranes of red blood cells, collected from fasting blood samples of each participant. At the same time, all subjects underwent cognitive tests aimed at assessing immediate memory, the type used each time data is stored and then forgotten. It emerged that in depressed individuals, levels of Omega-3 ALA in red blood cell membranes were significantly associated with immediate memory abilities.
A mosaic yet to be completed
The results add new details to the understanding of Omega-3 benefits on cognitive functions. According to the authors, the data suggest that low concentrations of these fatty acids in red blood cell membranes could predict cognitive problems in people with depression. Moreover, Omega-3 intake might be helpful if depression occurs in old age. Indeed, the scientists explain that in cases of depression, these nutrients can reduce cortisol levels, a molecule whose accumulation is linked to brain volume reduction associated with episodes of immediate memory loss.
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Source
1. Chiu CC, Frangou S, Chang CJ, Chiu WC, Liu HC, Sun IW, Liu SI, Lu ML, Chen CH, Huang SY, Dewey ME, Stewart R, “Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression”, Am J Clin Nutr. 2012 Feb;95(2):420-7. Epub 2012 Jan 4



